严兴荣 男 1977年生,博士,副教授,硕士研究生导师,毕业于西北农林科技大学动物医学院,2008年至今在威廉williamhill体育从事教学与科研工作。主讲《发育生物学》《胚胎工程》《实验动物学》等课程,主持多项校级教改项目。
研究方向:1. 利用腔前卵泡体外培养体系进行环境污染物及食品毒理学评价研究;2. 秦岭濒危野生动物(林麝、金丝猴和羚牛)种质资源保护与利用等相关研究;3. 小鼠胚胎发育和孤雌胚胎干细胞的研究,发表论文40余篇,主持多项国家级和省部级项目。积极参与社会活动,参与2024年咸阳市危化品企业应急预案编制,担任陕西省和西安市基层应急人员团队培训主讲教师,协助陕西省毒理学会和科协赴安康市镇坪县城关镇竹节溪村进行乡村振兴工作,协助陕西省毒理学会参与陕西省民政厅组织的“山阳县乡村振兴合力团”。担任中国医药技术协会生物安全委员会委员、生物科学与生物技术国家级实验教学示范中心(威廉williamhill体育)常务副主任,陕西省毒理学会秘书长,陕西省紧急救援协会理事,陕西省实验动物学会和陕西省动物学会理事。
发表文章:
1. Yang J, Luo W, Geng Y, Wei H, Wang J, Gao M, Tang J, Li M, Wang Y, Yan X. SSR Marker Acquisition and Application from Transcriptome of Captive Chinese Forest Musk Deer (Moschus berezovskii). Biochem Genet. 2024 Aug;62(4):3215-3230. (通讯)
2. Peng X, Khan Z, Liu XM, Deng SL, Fang YG, Zhang M, Su XH, Xing LX, Yan XR. Embryonic Development of Parthenogenetic and Sexual Eggs in Lower Termites. Insects. 2023 Jul 15;14(7):640.(通讯)
3. Luo W, Geng Y, Gao M, Cao M, Wang J, Yang J, Sun C, Yan X. Isolation and Identification of Bone Marrow Mesenchymal Stem Cells from Forest Musk Deer. Animals (Basel). 2022 Dec 20;13(1):17.(通讯)
4. Wang J, Liu X, Yang J, Guo H, Li J, Huo L, Zhao H, Wang X, Yan X, Li B, Sun Y. Effects of small-molecule compounds on fibroblast properties in golden snub-nosed monkey (Rhinopithecus roxellana). J Med Primatol. 2021 Dec;50(6):323-331.(通讯)
5. Liu X, Wei H, Yang J, Li J, Zhang P, Li Y, Hou R, Hua J, Yan X, Li B. Effect of bFGF on fibroblasts derived from the golden snub-nosed monkey. Primates. 2021 Mar;62(2):369-378. (通讯)
6. Xu W, Huo L, Li J, Xu C, Wang S, Yang Y, Liu C, Zheng X, Feng X, Yan X. Effects of Alcohol on Mitochondrial Functions of Cumulus Cells in Mice. Cell Reprogram. 2017 Apr;19(2):123-131.(通讯)
7. Li J, Wang S, Wang B, Wei H, Liu X, Hao J, Duan Y, Hua J, Zheng X, Feng X, Yan X. High-fat-diet impaired mitochondrial function of cumulus cells but improved the efficiency of parthenogenetic embryonic quality in mice. Anim Cells Syst (Seoul). 2018 Aug 22;22(4):243-252.(通讯)
8. Yan X, Yang Y, Liu W, Geng W, Du H, Cui J, Xie X, Hua J, Yu S, Li L, Chen F. Differentiation of neuron-like cells from mouse parthenogenetic embryonic stem cells. Neural Regen Res. 2013 Feb 5;8(4):293-300.
9. Yan X, Yu S, Lei A, Hua J, Chen F, Li L, Xie X, Yang X, Geng W, Dou Z. The four reprogramming factors and embryonic development in mice. Cell Reprogram. 2010 Oct;12(5):565-70.
10. Yan XR, Yang YH, Zheng XM, Cui JH, Xie X, Li LW, Chen FL, Hua JL, Zhang YS. Expression of FGF4 mRNA is mediated by mating behaviours in mice. Cell Biochem Funct. 2013 Aug;31(6):526-31.
11. Zhai H, Li D, Li M, Zou J, Liu F, Chen F, Yan X, Liu Y, Zhou W. Acylation modification of konjac glucomannan and its adsorption of Fe (Ⅲ) ion. Carbohydr Res. 2020 Nov;497:108133
12. Liu W, Yan X, Liu W, Wang Y, Rao Y, Yu H, Cui J, Xie X, Sun M, Yin L, Li H, Chen F. Alterations of protein glycosylation in embryonic stem cells during adipogenesis. Int J Mol Med. 2018 Jan;41(1):293-301
13. Liu W, Yin L, Yan X, Cui J, Liu W, Rao Y, Sun M, Wei Q, Chen F. Directing the Differentiation of Parthenogenetic Stem Cells into Tenocytes for Tissue-Engineered Tendon Regeneration. Stem Cells Transl Med. 2017 Jan;6(1):196-208
14. Sun M, Jiang M, Cui J, Liu W, Yin L, Xu C, Wei Q, Yan X, Chen F. A novel approach for the cryodesiccated preservation of tissue-engineered skin substitutes with trehalose. Mater Sci Eng C Mater Biol Appl. 2016 Mar;60:60-66
15. Liu W, Yang X, Yan X, Cui J, Liu W, Sun M, Rao Y, Chen F. Directing parthenogenetic stem cells differentiate into adipocytes for engineering injectable adipose tissue. Stem Cells Int. 2014;2014:423635.
16. Geng W, Yan X, Du H, Cui J, Li L, Chen F. Immunization with FSHβ fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model. Biochem Biophys Res Commun. 2013 May 3;434(2):280-6.
17. Zhao J, Liu L, Wei J, Ma D, Geng W, Yan X, Zhu J, Du H, Liu Y, Li L, Chen F. A novel strategy to engineer small-diameter vascular grafts from marrow-derived mesenchymal stem cells. Artif Organs. 2012 Jan;36(1):93-101.
18. Xie X, Wang C, Xie Y, Wang X, Chen G, Yan X, Cui J, Chen F, Li H, Jin B. Development and evaluation of a sandwich ELISA method for the detection of human CD306. J Immunol Methods. 2013 Oct 31;396(1-2):65-73.
19. Rao Y, Cui J, Yin L, Liu W, Liu W, Sun M, Yan X, Wang L, Chen F. Preclinical study of mouse pluripotent parthenogenetic embryonic stem cell derivatives for the construction of tissue-engineered skin equivalent. Stem Cell Res Ther. 2016 Oct 22;7(1):156.
20. Xie X, Wu X, Cui J, Li H, Yan X. Increase ICAM-1 and LFA-1 expression by cerebrospinal fluid of subarachnoid hemorrhage patients: involvement of TNF-α. Brain Res. 2013 May 28;1512:89-96.
21. Guo Y, Li H, Wang Y, Yan X, Sheng X, Chang D, Qi X, Wang X, Liu Y, Li J, Ni H. Screening somatic cell nuclear transfer parameters for generation of transgenic cloned cattle with intragenomic integration of additional gene copies that encode bovine adipocyte-type fatty acid-binding protein (A-FABP). Mol Biol Rep. 2017 Feb;44(1):159-168.
22. Yu S, Yan X, Liu H, Cai X, Cao S, Shen L, Zuo Z, Deng J, Ma X, Wang Y, Ren Z. Improved establishment of embryonic stem (ES) cell lines from the Chinese Kunming mice by hybridization with 129 mice. Int J Mol Sci. 2014 Feb 25;15(3):3389-402.
23. Liu L, Wu W, Tuo X, Geng W, Zhao J, Wei J, Yan X, Yang W, Li L, Chen F. Novel strategy to engineer trachea cartilage graft with marrow mesenchymal stem cell macroaggregate and hydrolyzable scaffold. Artif Organs. 2010 May;34(5):426-33.
24. Shi F, Duan S, Cui J, Yan X, Li H, Wang Y, Chen F, Zhang L, Liu J, Xie X. Induction of matrix metalloproteinase-3 (MMP-3) expression in the microglia by lipopolysaccharide (LPS) via upregulation of glycoprotein nonmetastatic melanoma B (GPNMB) expression. J Mol Neurosci. 2014;54(2):234-42.
25. Geng W, Ma D, Yan X, Liu L, Cui J, Xie X, Li H, Chen F. Engineering tubular bone using mesenchymal stem cell sheets and coral particles. Biochem Biophys Res Commun. 2013 Apr 19;433(4):595-601.
26. Zhang R, Gao Z, Geng W, Yan X, Chen F, Liu Y. Engineering vascularized bone graft with osteogenic and angiogenic lineage differentiated bone marrow mesenchymal stem cells. Artif Organs. 2012 Dec;36(12):1036-46.
27. Zhou W, Han C, Song Y, Yan X, Li D, Chai Z, Feng Z, Dong Y, Li L, Xie X, Chen F, Zhao Y. The performance of bone marrow mesenchymal stem cell--implant complexes prepared by cell sheet engineering techniques. Biomaterials. 2010 Apr;31(12):3212-21.
28. Hongmin L, Wei Z, Xingrong Y, Jing W, Wenxin G, Jihong C, Xin X, Fulin C. Osteoinductive nanohydroxyapatite bone substitute prepared via in situ hydrothermal transformation of cuttlefish bone. J Biomed Mater Res B Appl Biomater. 2015 May;103(4):816-24.
29. 王炎,王娟娟,杨静,等.圈养与野生川金丝猴应激水平的比较研究[J].野生动物学报,2022,43(03):623-628.(通讯)
30. 贾佳,郭含星,王娟娟,等.羚牛骨髓间充质干细胞的分离培养与鉴定[J].西北农业学报,2022,31(05):535-543.(通讯)
31. 唐婕,杨静,索丽娟,等.林麝粪便孕酮提取方法的改进[J].经济动物学报,2022,26(01):19-22+28.(通讯)
32. 唐婕,李晶晶,王波,等.林麝粪便中睾酮HLPC和ELISA检测方法的比较[J].动物医学进展,2019,40(02):99-104.(通讯)
33. 唐婕,李晶晶,王波,等.空气暴露时间对林麝粪便孕酮水平的影响[J].动物医学进展,2018,39(08):44-49.(通讯)
34. 唐婕,李晶晶,王波,等.两种方法从林麝粪便提取DNA效率及分析[J].西北农业学报,2018,27(03):326-330.(通讯)
35. 胡军,程妮,钟占强,等.丙戊酸钠对人胶质瘤干细胞增殖和凋亡的影响[J].基因组学与应用生物学,2017,36(06):2235-2240.(通讯)
36. 谈彦玲,党玉蕾,张宏贵,等.两种散白蚁两性生殖与孤雌生殖胚胎发育比较研究[J].昆虫学报,2016,59(04):438-445.
37. 许春丽,许婉璐,霍莉慧,等.小鼠孤雌激活来源囊胚线粒体基因表达[J].基因组学与应用生物学,2015,34(11):2357-2361.(通讯)
38. 赵敬贤,李娟,严兴荣,等.FABP4转基因牛的分子生物学鉴定[J].中国农业科学,2014,47(24):4895-4903.
39. 冯秀亮,刘淑娟,段艳萍,等.三种方法对细胞周期诱导效率的比较[J].基因组学与应用生物学,2014,33(04):756-760.(通讯)
40. 梁少楠,李宇恒,许春丽,等.应用凝集素芯片检测系统性红斑狼疮红细胞膜表面糖链变化[J].基因组学与应用生物学,2014,33(04):722-728.(通讯)
41. 严兴荣,丁向彬,葛秀国,等.慢病毒介导的牛生长素基因对小鼠胚胎发育的研究[J].基因组学与应用生物学,2013,32(01):8-13.(通讯)
42. 严兴荣,杨艳红,丁向彬,等.秦川牛胎儿成纤维细胞表达A-FABP基因条件的优化和鉴定[J].基因组学与应用生物学,2012,31(06):544-548.(通讯)
43. 田静,赵刚,钟刚毅,等.不同交配时间对小鼠胚胎收集和发育的影响[J].西北农林科技大学学报(自然科学版),2012,40(07):21-24+31.(通讯)
44. 严兴荣,余树民,雷安民,等.父系遗传背景对小鼠超排效果及孤雌胚胎体外发育的影响[J].西北农林科技大学学报(自然科学版),2008,(06):1-4.(通讯)
45. 严兴荣,余树民,雷安民,等.父系遗传背景对小鼠体细胞核移植效率的影响[J].动物学报,2007,(06):1101-1106.(通讯)